Slide 3: Tiled wall at the ‘Hotel Villa Eos’, Agrigento, Sicily. April 2003 Slide 4: In acid solutions it is negatively charged and attaches by salt bridges to positively charged sites, including basic proteins in eosinophil granules Slide 5: Ehrlich P. (1879) Beitrage zur Kenntniss der granulirten bindergewebszellen und der eosinophilen leukocyten. Arch Anat Physiol Lpz 3 Physiol Abt, pp. 166-9 Hirsch J G, Hirsch B I. (1980) Paul Ehrlich and the discovery of the eosinophil. In: Mahmoud A A, Austen K F, Simon A S. Eds. 'The Eosinophil in Health and Disease'. Grune and Stratton. New York, 3-23. Slide 6: Brown T R. (1898) Studies on trichinosis with especial reference to the increase of the eosinophilic cells in the blood and muscle, the origin of these cells and their diagnostic importance. J Exp Med 3, 315-47. Ehrlich’s triple stain :Orange G, acid fuchsin & methyl green Gollasch Dr. (1889) Zur kenntniss der asthmatischen sputums. Fortschritte der Medizin (Berlin) 7, 361-5. Dunger R. (1910) Eine einfache Methode der Sahlung der eosinophilen Leukozyten und der praktische Wert dieser Untersuchung. Munch Med Wschr 57, 1942-4 Slide 7: Shapiro L G. (1919) Eosinophilic (polymorphonuclear) leukemia. Report of a case with autopsy (abstracted). Proc New York Path Soc 19, 73-83 Slide 9: Reinbach G. (1893) Ueber das Verhalten der Leukocyten bei malignen Tumoren. Arch Klin Chir 46, 486-562. Löffler W. (1936) Endocarditis parietalis fibroplastica mit Bluteosinophilie, in eigenartiger Krankheitsbild. Schweiz Med Wochenschr 17, 817-20 Slide 10: Stillman R G. (1912) A case of myeloid leukemia with predominance of eosinophile cells. Med Record 81, 594-5 McDonald S, Shaw A F. (1922) Persistent eosinophilia and splenomegaly. Br Med J 2, 966-71 Punch A L, Close H G. (1938) A case of unexplained eosinophilia. Guy's Hosp Rep 88, 143-9 Slide 11 Hardy W R, Anderson R E. (1968) The hypereosinophilic syndromes. Ann Intern Med 68, 1220-9 Benvenisti D S, Ultmann J E. (1969) Eosinophilic leukemia. Report of five cases and review of the literature. Ann Intern Med 71, 731-45: Slide 12 Bousser J. (1957) Eosinophilie et leucemie. Sang 28, 553-80: Slide 13: Chusid M J, Dale D C, West B C, Wolff S M. (1975) The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 54, 1-27 Fauci A S, Harley J B, Roberts W C, Ferrans V J, Gralnick H R, Bjornson B H. (1982) NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med 97, 78-92 Slide 14: Basten A, Beeson P B. (1970) Mechanisms of eosinophilia. II. Role of the lymphocyte. J Exp Med 131, 1288-305 Slide 16: Carey J P, Burke A C. (1982) Transient hypereosinophilia in the infant of a mother with hypereosinophilic syndrome (letter). Arch Intern Med 142, 1754-5 Campbell H D, Tucker W Q, Hort Y, Martinson M E, Mayo G, Clutterbuck E J, Sanderson C J, Young I G. (1987) Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Proc Natl Acad Sci USA 84, 6629-33 Simon HU, Plotz SG, Simon D, Dummer R, Blaser K. (2001) Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia. Int Arch Allergy Immunol 124, 242-5. Slide 17: Goh K, Swisher S N, Rosenberg C A. (1965) Cytogenetic studies of eosinophilic leukemia and chronic myelocytic leukemia. Ann Intern Med 62, 80-6 Goldman J M, Najfeld V, Th'ng K H. (1975) Agar culture and chromosome analysis of eosinophilic leukaemia. J Clin Pathol 28, 956-61 Luppi et al. (1994) Clonal nature of hypereosinophilic syndrome. Blood 84, 349-50 Cools J et al. (2003) A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of Imatinib in idiopathic hypereosinophilic syndrome. New Eng J Med 348, 1201-14 Slide 18: Roufosse F, Cogan E, Goldman M. The hypereosinophilic syndrome revisited. Annu Rev Med. 2003; 54:169-84. Slide 19: Rigau Perez J G, Perez Alvarez L, Duenas Castro S, Choi K, Thacker S B, Germain J L, Gonzalez de Andres G, Canada Royo L, Perez Gallardo F. (1984) Epidemiologic investigation of an oil-associated pneumonic paralytic eosinophilic syndrome in Spain. Am J Epidemiol 119, 250-60 Mecucci C, Bosly A, Michaux J L, Broeckaert-Van Orshoven A, Van den Berghe H. (1985) Cancer Genet Cytogenet. 1985 17, 359-63. Gleich G J, Schroeter A L, Marcoux J P, Sachs M I, O'Connell E J, Kohler P F. (1984) Episodic angioedema associated with eosinophilia. N Engl J Med. 1984, 310, 1621-6. Slide 20: Spry C J, Take M, Tai P C. (1985) Eosinophilic disorders affecting the myocardium and endocardium: a review. Heart Vessels Suppl 1, 240-2 Slide 21: Davies,J. Sapsford,R. Brooksby,I. Olsen,E.G.J. Spry,C.J. Oakley,C.M. Goodwin,J.F. (1981). Successful surgical treatment of two patients with eosinophilic endomyocardial disease. Brit. Heart J. 46 438-445. Slide 22: Tai P C, Ackerman S J, Spry C J, Dunnette S, Olsen E G, Gleich G J. (1987) Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease. Lancet 1, 643-7. Slide 26: Chaine,G. Davies,J. Kohner,E.M. Hawarth,S. Spry,C.J. (1982). Ophthalmological abnormalities in the hypereosinophilic syndrome. Ophthalmol. 89 1348-1356.